The CIFOR guidelines provide comprehensive model practices for foodborne disease outbreak management, covering the entire response cycle from preparation and detection through investigation, control, and follow-up while defining clear organizational roles. This third edition incorporates significant advances including whole genome sequencing, advanced molecular detection, and culture-independent diagnostic testing, while emphasizing integrated consumer complaint systems, sub-cluster investigations, epidemiologic tracebacks, and environmental assessments. The updated guidelines also feature enhanced communication coordination, improved after-action review processes, and streamlined program metrics.